This article has been out since Friday but it’s still timely given that we had yet another strong quake/aftershock this morning at 12:40 am (which I did not feel). Apparently, there is some disagreement as to weather these quakes make “The Big One” more or less likely. The thinking is that these small quakes may either be a prelude, a trigger really, for a massive upheaval from the infamous New Madrid fault, or they could be providing relief to the geological stresses beneath our feat that make a huge quake less likely.
As usual, no one knows for sure. But go read the article for the specifics of both arguments.